Gluten Immunochemistry

Gluten Immunochemistry

The immunochemistry of Triticeae glutens is important in several inflammatory diseases. It can be subdivided into innate responses (direct stimulation of immune system), class II mediated presentation (HLA DQ), class I meditiated stimulation of killer cells, and antibody recognition. The responses to gluten proteins and polypeptide regions differs according to the type of gluten sensitivity. The response is also dependent on the genetic makeup of the human leukocyte antigen genes. In gluten sensitive enteropathy, there are 4 types of recognition, innate immunity (a form of cellular immunity priming), HLA-DQ, and antibody recognition of gliadin and transglutaminase. With idiopathic gluten sensitivity only antibody recognition to gliadin has been resolved. In wheat allergy, the response pathways are mediated through IgE against other wheat proteins and other forms of gliadin.

Read more about Gluten Immunochemistry:  Innate Immunity, HLA Class I Restrictions To Gliadin, HLA-DQ Recognition of Gluten, Antibody Recognition, Taming Triticeae Immunochemistry

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Gluten Immunochemistry - Taming Triticeae Immunochemistry
... one of a several dozen known motifs whereas only a small fraction of Triticeae gluten variants have been examined ... For this reason the immunochemistry is best discussed at the level of Triticeae, because it is clear that the special immunological properties of the proteins appear to ... There are many gluten proteins, 3 genomes with many genes each for alpha, gamma, and omega gliadins ...

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    Ralph Waldo Emerson (1803–1882)