Type II Topoisomerase

Type II Topoisomerase

Type II topoisomerases cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP, unlike Type I topoisomerase. In this process, these enzymes change the linking number of circular DNA by ±2.

Read more about Type II Topoisomerase:  Function, Topology Simplification, Classification, Structure of Type IIA Topoisomerases, Structures of Type IIB Topoisomerases, Strand Passage Mechanism of Type II Topoisomerases, DNA Cleavage Mechanism of Type IIA Topoisomerases, Catenation, Inhibition

Other articles related to "type ii topoisomerase, type ii topoisomerases, type, ii":

Type II Topoisomerase - Inhibition
... Small molecules that target type II topoisomerase are divided into two classes inhibitors and poisons ... Inhibitors of type II topoisomerase include HU-331, ICRF-187, ICRF-193, and mitindomide ... Poisons of type II topoisomerases include etoposide, novobiocin, quinolones (including ciprofloxacin), and teniposide ...
4-8-2 - Usage - South Africa
... Between 1909, when the world’s first true Mountain type tender locomotive was placed in service by the NGR, and 1953 when the Class 25 and Class 25NC 4-8-4 Northern ... In 1909 the NGR placed the world’s first true Mountain type locomotive in service when the first of thirty Class Hendrie D 4-8-2 tender locomotives ... batches over a period of eight years spanning World War II ...

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