Fluorous Chemistry - Partition Coefficients

Partition Coefficients

The fluorous character of a molecule can be assessed by its partition coefficient between a perfluorocarbon and a hydrocarbon. In the following table, the data are for perfluoromethylcyclohexane:toluene.

solute partition coefficient
for CF3C6F11:toluene
octane 5.4:94.6
CH3(CH2)13CH=CH2 0.9:99.1
C6H6 6:94
C6F6 28.0:72.0
C10F22(CH2)3OH 80.5:19.5
C8F20(CH2)3C6H5 49.5:50.5
C8F20C6H5 77.5:22.5

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