DNA Microarray

A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Each DNA spot contains picomoles (10−12 moles) of a specific DNA sequence, known as probes (or reporters or oligos). These can be a short section of a gene or other DNA element that are used to hybridize a cDNA or cRNA (also called anti-sense RNA) sample (called target) under high-stringency conditions. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine relative abundance of nucleic acid sequences in the target.

Read more about DNA Microarray:  The Basic Microarray, History, Principle, Uses and Types, Microarrays and Bioinformatics

Other articles related to "dna microarray, dna, microarray":

DNA Microarray - Microarrays and Bioinformatics - Data Warehousing
... Microarray data was found to be more useful when compared to other similar datasets ... The sheer volume of data, specialized formats (such as MIAME), and curation efforts associated with the datasets require specialized databases to store the data ...
DNA Microarray Experiment
... This is an example of a DNA microarray experiment, detailing a particular case to better explain DNA microarray experiments, while enumerating possible alternatives ... this can be all RNA for expression profiling, DNA for comparative hybridization, or DNA/RNA bound to a particular protein which is immunoprecipitated (ChIP-on-chip) for epigenetic or ... >1μg, although the required amount varies by microarray platform), the experiment can proceed ...
Edwin Southern - Career - DNA Microarray
... Southern founded Oxford Gene Technology (OGT), a company that developed DNA microarray technology ... Affymetrix based on his patent holdings in microarray technology ...

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