Increasing calcidiol levels are associated with increasing fractional absorption of calcium from the gut up to levels of 80 nmol/L (32 ng/mL). Urinary calcium excretion balances intestinal calcium absorption and does not increase with calcidiol levels up to ~400 nmol/L (160 ng/mL).
A study by Cedric F. Garland and Frank C. Garland of the University of California, San Diego analyzed the blood from 25,000 volunteers from Washington County, Maryland, finding that those with the highest levels of calcifediol had a risk of colon cancer that was one-fifth of typical rates.
Famous quotes containing the word significance:
“The hysterical find too much significance in things. The depressed find too little.”
—Mason Cooley (b. 1927)