What is genotype?

  • (noun): A group of organisms sharing a specific genetic constitution.
    See also — Additional definitions below


The genotype is the genetic makeup of a cell, an organism, or an individual (i.e. the specific allele makeup of the individual) usually with reference to a specific character under consideration. For instance, the human CFTR gene, which encodes a protein that transports chloride ions across cell membranes, can be dominant (A) as the normal version of the gene, or recessive (a) as a mutated version of the gene. Individuals receiving two recessive alleles will be diagnosed with Cystic fibrosis. It is generally accepted that inherited genotype, transmitted epigenetic factors, and non-hereditary environmental variation contribute to the phenotype of an individual.

Read more about Genotype.

Some articles on genotype:

... of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference ... a small fraction of an individual’s genotype is determined ... a single genomic region may be all that needs to be examined to determine the genotype ...
Determining Genotype
... Genotyping is the process of elucidating the genotype of an individual with a biological assay ... MSI and LOH in particular have been associated with cancer cell genotypes for colon, breast and cervical cancer ... allow only a fraction of an individual’s genotype to be determined efficiently ...
... Telaprevir is only indicated for use against hepatitis c genotype 1 viral infections and hasn´t been proven to have an effect on or being safe when used ... of pegylated interferon and ribavirin is less effective on genotype 1 and telaprevir offers a welcome addition to the treatment of this genotype ...
The Mendelian Randomization Approach
... Importantly, the genotype must only affect the disease status indirectly via its effect on the exposure of interest ... Because genotypes are assigned randomly when passed from parents to offspring during meiosis, if we assume that choice of mate is not associated with genotype (panmixia ... the technique of instrumental variables (Thomas Conti 2004, Didelez Sheehan 2007), with genotype acting as an instrument for the exposure of interest ...

More definitions of "genotype":

  • (noun): The particular alleles at specified loci present in an organism.
    Synonyms: genetic constitution