Thiamine

Thiamine or thiamin or vitamin B1 ( /ˈθaɪ.əmɨn/ THY-ə-min), named as the "thio-vitamine" ("sulfur-containing vitamin") is a water-soluble vitamin of the B complex. First named aneurin for the detrimental neurological effects if not present in the diet, it was eventually assigned the generic descriptor name vitamin B1. Its phosphate derivatives are involved in many cellular processes. The best-characterized form is thiamine pyrophosphate (TPP), a coenzyme in the catabolism of sugars and amino acids. Thiamine is used in the biosynthesis of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). In yeast, TPP is also required in the first step of alcoholic fermentation.

All living organisms use thiamine in their biochemistry, but it is synthesized only in bacteria, fungi, and plants. Animals must obtain it from their diet, and thus, for them, it is an essential nutrient. Insufficient intake in birds produces a characteristic polyneuritis. In mammals, deficiency results in Korsakoff's syndrome, optic neuropathy, and a disease called beriberi that affects the peripheral nervous system (polyneuritis) and/or the cardiovascular system. Thiamine deficiency has a potentially fatal outcome if it remains untreated. In less severe cases, nonspecific signs include malaise, weight loss, irritability and confusion.

There is still much research devoted to elucidating the exact mechanisms by which thiamine deficiency leads to the specific symptoms observed (see below). New thiamine phosphate derivatives have recently been discovered, emphasizing the complexity of thiamine metabolism.

Thiamine derivatives with improved pharmacokinetics have been discovered and are to be considered more effective in alleviating the symptoms of thiamine deficiency and other thiamine-related conditions such as impaired glucose metabolism in diabetes. These compounds include allithiamine, prosultiamine, fursultiamine, benfotiamine, and sulbutiamine, among others.

Read more about ThiamineChemical Properties, Biosynthesis, Thiamine Phosphate Derivatives and Function, Deficiency, Genetic Diseases, History, Research

Other articles related to "thiamine":

Sulbutiamine
... Sulbutiamine (brand name Arcalion) is a synthetic derivative of thiamine (vitamin B1) ... As a dimer of two modified thiamine molecules, it is a lipophilic compound that crosses the blood–brain barrier more readily than thiamine and increases the levels of thiamine and ... in an effort to develop more useful thiamine derivatives since it was hoped that increasing the lipophilicity of thiamine would result in better ...
TPK1
... TPK1 Gene EC number 2.7.6.2 Gene Ontology Molecular function • thiamine diphosphokinase activity • ATP binding • kinase activity Cellular component • cytoplasm • cytosol Biological process ... a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate ...
Factors Affecting Retrospective Memory - Disease - Korsakoff's Syndrome
... Korsakoff's is caused by a severe thiamine (vitamin B1) deficiency due to chronic alcoholism or malnourishment ... Thiamine is necessary for the body to process carbohydrates ... This thiamine dificiency can lead to symptoms such as confusion, loss of balance, drowsiness, and some specific problems with vision ...
Thiamine - Research - Persistent Carbenes
... The production of furoin from furfural is catalyzed by thiamine through a relatively stable carbene (an organic molecule containing unbonded valence electrons pairs at a carbon center) ...
Amprolium - Synthesis
... The drug is a thiamine analogue and blocks the thiamine transporter of Eimeria species ... By blocking thiamine uptake it prevents carbohydrate synthesis ...