Renal Cell Carcinoma

Renal cell carcinoma (RCC, also known as hypernephroma) is a kidney cancer that originates in the lining of the proximal convoluted tubule, the very small tubes in the kidney that filter the blood and remove waste products. RCC is the most common type of kidney cancer in adults, responsible for approximately 80% of cases. It is also known to be the most lethal of all the genitourinary tumors. Initial treatment is most commonly a radical or partial nephrectomy and remains the mainstay of curative treatment. Where the tumor is confined to the renal parenchyma, the 5-year survival rate is 60-70%, but this is lowered considerably where metastases have spread. It is relatively resistant to radiation therapy and chemotherapy, although some cases respond to immunotherapy. Targeted cancer therapies such as sunitinib, temsirolimus, bevacizumab, interferon-alpha, and sorafenib have improved the outlook for RCC (progression-free survival), although they have not yet demonstrated improved survival.

Read more about Renal Cell Carcinoma:  Signs and Symptoms, Classification, Epidemiology, Diagnosis, Prognosis, Treatment, Metastatic Renal Cell Carcinoma, Adjuvant Therapy in Renal Cell Carcinoma, History

Other articles related to "renal cell carcinoma, carcinoma":

... and has been successful in trials with renal cell carcinoma (RCC) and several other tumor types ... In 2010, a Phase III trial for previously treated metastatic renal cell carcinoma (mRCC) showed significantly extended progression-free survival when compared ... to recommend the approval of axitinib for the second-line treatment of patients with advanced renal cell carcinoma (RCC), based on the results of the Phase III trial ...
Renal Cell Carcinoma - History
... This section requires expansion Historically, RCC was also known as nephrocellular carcinoma ... Paul Grawitz first described renal cell carcinoma in 1883 ...
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... Hypertension (HTN) was found to be a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib ...

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