Association With Cancer
Recently there has been much interest in abnormal levels of expression of microRNAs in cancers. Upregulation of miR-10 has been found in a number of cancers. Increased levels of miR-10a have been found in glioblastoma, anaplastic astrocytomas, primary hepatocellular carcinomas and colon cancer. Increased levels of miR-10b have been found in glioblastoma, anaplastic astrocytomas, pancreatic cancer, and metastatic breast cancer. Although high expression of miR-10b is found in metastatic breast cancers, it does not appear to be present at high levels in early breast cancers.
Downregulation of miR-10a has been found in chronic myeloid leukemia. USF2, a target gene of miR-10a, has been found to be overexpressed in these leukemias. Downregulation of miR-10a has also been found in acute myeloid leukemia, the most common acute leukemia affecting adults. Conversely, miR-10a and miR-10b have found to be upregulated in acute myeloid leukemia with NPM1 mutations; these account for approximately a third of adult acute myeloid leukemia cases and contain mutations in the NPM1 gene which result in the relocation of NPM1 from the nucleus to the cytoplasm. Upregulation of miR-10b has also been found in B-cell chronic lymphocytic leukemia, the most common type of leukemia.
Genomic copy number abnormalities involving microRNA genes (both increases and decreases in copy number) have been found in cancers. A gain in copy number of the mir-10a gene has been found in melanoma and breast cancer.
Upstream of the mir-10b gene is a promoter region containing a binding site for the Twist transcription factor (Twist). Binding of Twist to this promoter region induces miR-10b expression, leading to a reduced translation of the tumour suppressor HOXD10. This results in upregulation of RhoA/RhoC, Rho kinase activation and tumour cell invasion.
Read more about this topic: Mir-10 Micro RNA Precursor Family
Other articles related to "association with cancer, association with, cancer":
... Equine sarcoid, a naturally occurring skin tumour affecting horses, donkeys and mules, is associated with strains of BPV-1/2 which may be equine specific ... The lesions can occur anywhere on the body, often multiply, with the limbs, thorax–abdomen, head and paragenital areas being particularly commonly affected ...
... in embryogenesis clearly indicates a close association with hormonal fluctuations in developing cells ... to date, the presence of EVI1 in cancer has not been linked to aberrant production of any hormones or hormone receptors ...
Famous quotes containing the words association with, cancer and/or association:
“Association with other people corrupts our character Mespecially when we have none.”
—Friedrich Nietzsche (18441900)
“The truth is that Mozart, Pascal, Boolean algebra, Shakespeare, parliamentary government, baroque churches, Newton, the emancipation of women, Kant, Marx, and Balanchine ballets dont redeem what this particular civilization has wrought upon the world. The white race is the cancer of human history.”
—Susan Sontag (b. 1933)
“The spiritual kinship between Lincoln and Whitman was founded upon their Americanism, their essential Westernism. Whitman had grown up without much formal education; Lincoln had scarcely any education. One had become the notable poet of the day; one the orator of the Gettsyburg Address. It was inevitable that Whitman as a poet should turn with a feeling of kinship to Lincoln, and even without any association or contact feel that Lincoln was his.”
—Edgar Lee Masters (18691950)