Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs).
Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodies, hormones, etc.). Inorganic and organometallic compounds are also useful as drugs (e.g., lithium and platinum-based agents such as lithium carbonate and cis-platin.
In particular, medicinal chemistry in its most common guise—focusing on small organic molecules—encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for purpose of medicinal products.
At the biological interface, medicinal chemistry combines to form a set of highly interdisciplinary sciences, setting its organic, physical, and computational emphases alongside biological areas such as biochemistry, molecular biology, pharmacognosy and pharmacology, toxicology and veterinary and human medicine; these, with project management, statistics, and pharmaceutical business practices, systematically oversee altering identified chemical agents such that after pharmaceutical formulation, they are safe and efficacious, and therefore suitable for use in treatment of disease.
Read more about Medicinal Chemistry: Training in Medicinal Chemistry
Other articles related to "medicinal":
... Medicinal use of cannabis is legal in a number of countries, including Canada, the Czech Republic and Israel ... widely at the state level and some states have established medicinal marijuana programs in violation of federal law two states (Colorado and Washington ... jurisdictions permit cannabis use for medicinal purposes ...
... See also Medicinal mushrooms Certain mushrooms enjoy usage as therapeutics in folk medicines, such as Traditional Chinese medicine ... Notable medicinal mushrooms with a well-documented history of use include Agaricus subrufescens, Ganoderma lucidum, and Ophiocordyceps sinensis ...
... Sundews were used as medicinal herbs as early as the 12th century, when an Italian doctor from the School of Salerno, Matthaeus Platearius, described the plant as an herbal remedy for coughs under the name ... Medicinal preparations are primarily made using the roots, flowers, and fruit-like capsules ...
... of Canada awarded a four-year contract to a Saskatoon-based company for the production of medicinal marijuana ... owned by the Hudson Bay Mining and Smelting Company to produce approximately 400 kilograms of medicinal marijuana annually ... lack of consistency in the early crops of medicinal marijuana ...
Famous quotes containing the words chemistry and/or medicinal:
“For me chemistry represented an indefinite cloud of future potentialities which enveloped my life to come in black volutes torn by fiery flashes, like those which had hidden Mount Sinai. Like Moses, from that cloud I expected my law, the principle of order in me, around me, and in the world.... I would watch the buds swell in spring, the mica glint in the granite, my own hands, and I would say to myself: I will understand this, too, I will understand everything.”
—Primo Levi (19191987)
“Our Indian said that he was a doctor, and could tell me some medicinal use for every plant I could show him ... proving himself as good as his word. According to his account, he had acquired such knowledge in his youth from a wise old Indian with whom he associated, and he lamented that the present generation of Indians had lost a great deal.”
—Henry David Thoreau (18171862)