Kinases

Some articles on kinase, kinases:

SPAG9
... SPAG9 Gene Gene Ontology Molecular function • JUN kinase binding • kinesin binding • mitogen-activated protein kinase p38 binding Cellular component ... signals are transduced into cells through mitogen-activated protein kinases ... The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering ...
Ca2+/calmodulin-dependent Protein Kinase
... Ca2+/calmodulin-dependent protein kinases II or CaM kinases II are serine/threonine-specific protein kinases that are regulated by the Ca2+/calmodulin ...
C-Jun N-terminal Kinases
... c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain ... They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock ... (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII ...
Lim Kinase
... LIM kinase-1 (LIMK1) and LIM kinase-2 (LIMK2) are actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins ... substrates yet identified for the LIM kinases ... is regulated by Pak1, and LIMK2 by the Rho-dependent kinase ROCK ...
SUGEN - Early History and Focus
... investor Stephen Evans-Freke and kinase researchers Joseph Schlessinger and Axel Ullrich ... Sugen developed small-molecule inhibitors of protein kinases, key enzymes in signal transduction and cellular decision-making ... The concept of inhibiting kinases by small molecules that mimicked the ATP structure was generally thought to be infeasible when the company was founded (due ...