Eukaryotic Initiation Factor

Eukaryotic Initiation Factor

Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. They function in forming a complex with the 40S ribosomal subunit and Met-tRNAi called the 43S preinitation complex (PIC), recognizing the 5' cap structure of mRNA and recruiting the 43S PIC to mRNA, promoting ribosomal scanning of mRNA and regulating recognition of the AUG initiation codon, and joining of the 60S ribosomal subunit to create the 80S ribosome. There exist many more eukaryotic initiation factors than prokaryotic initiation factors due to greater biological complexity of eukaryotic cells.

The protein RLI is known to have an essential, probably catalytic role in the formation of initiation complexes as well.

Read more about Eukaryotic Initiation Factor:  EIF4 (eIF4F), EIF1 & EIF3, EIF2, EIF5 & EIF5B, EIF6

Other articles related to "factor, eukaryotic initiation factor, initiations, initiation":

Dorian Bevec - Scientific Career - Selected Publications
... a muramyl peptide based on its lack of activation of nuclear factor - kappa B as a potential adjuvant for AIDS vaccines ... Tumor necrosis factor-alfa and Interleukin-1 beta mRNA expression in HMC-1 cells Differential regulation of gene product expression by recombinant IL-4 ... Eukaryotic initiation factor 5A is a cellular target of the HIV-1 Rev activation domain mediating trans-activation ...
Mircea Eliade - Psychological Effects of Initiations
... experiments in psychology have shown that severe initiations produce cognitive dissonance ... Rewards during initiations have important consequences in that initiates who feel more rewarded express stronger group identity ... As well as group attraction, initiations can also produce conformity among new members ...
Sri Abhinava Vidyatirtha - Initiation
... The sacred initiation ceremony was held on May 22, 1931 ... was only thirteen years old at the time of his initiation into Sannyasa (Asceticism) ...
factors" class="article_title_2">List Of Me SH Codes (D12.776) - MeSH D12.776.835 -- Ribosomal Proteins - MeSH D12.776.835.725 -- Peptide Initiation Factors - MeSH D12.776.835.725.868 -- Eukaryotic Initiation Factors
... MeSH D12.776.835.725.868.124 -- eukaryotic initiation factor-1 MeSH D12.776.835.725.868.249 -- eukaryotic initiation factor-2 MeSH D12.776.835.725.868.374 ...

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