Trinucleotide Repeat Disorder

Trinucleotide Repeat Disorder

Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by trinucleotide repeat expansion, a kind of mutation where trinucleotide repeats in certain genes exceed the normal, stable threshold, which differs per gene. The mutation is a subset of unstable microsatellite repeats that occur throughout all genomic sequences. If the repeat is present in a healthy gene, a dynamic mutation may increase the repeat count and result in a defective gene.

Trinucleotide repeats are sometimes classified as insertion mutations and sometimes as a separate class of mutations.

Read more about Trinucleotide Repeat Disorder:  Summary, History, Symptoms, Genetics, Types, Trinucleotide Repeat Expansion

Other articles related to "trinucleotide repeat disorder, trinucleotide repeat, repeat, disorder, trinucleotide, repeats":

expansion" class="article_title_2">Trinucleotide Repeat Disorder - Trinucleotide Repeat Expansion
... Trinucleotide repeat expansion, also known as triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized as a trinucleotide ... Due to the tandem repeats in the DNA sequence and the instability of the sequence in these regions, 'loop out' structures may form during DNA replication while maintaining complementary base paring between the ... result in an increase in the number of repeats ...
Trinucleotide Repeat Disorders - Trinucleotide Repeat Expansion
... Trinucleotide repeat expansion, also known as triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized as a trinucleotide repeat disorder ... Due to the tandem repeats in the DNA sequence and the instability of the sequence in these regions, 'loop out' structures may form during DNA replication while ... sequence on the daughter strand this will result in an increase in the number of repeats ...

Famous quotes containing the words disorder and/or repeat:

    A. Well, an old order is a violent one.
    This proves nothing. Just one more truth, one more
    Element in the immense disorder of truths.
    Wallace Stevens (1879–1955)

    All official institutions of language are repeating machines: school, sports, advertising, popular songs, news, all continually repeat the same structure, the same meaning, often the same words: the stereotype is a political fact, the major figure of ideology.
    Roland Barthes (1915–1980)