Islets of Langerhans
Islet cell transplantation has the possibility of restoring beta cells and curing diabetes.
The Chicago Project headed at University of Illinois at Chicago Medical Center is investigating ways to regenerate beta cells in vivo. With that being said, beta cells experience apoptosis early and thus are destroyed within a normal-functioning pancreas. The source of this seems to come from the transfer of Pander, a gene that works by attaching to RNA. Pander, when active, causes the beta cells to be blocked at S phase, which induces apoptosis. This loss of beta cell mass eventually leads to a loss of most of the transplanted beta cells.
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