Seco may refer to:
- Seco, Kentucky, a small town in the United States
- Seco Herrerano, the national alcoholic beverage of Panamá
- Seco Rail, a French railway company
- Figueira Seco, a village on Maio in the Republic of Cape Verde
- Rancho Seco Nuclear Generating Station, a decommissioned nuclear power station in California
- Seco (butterfly), a genus of metalmark butterflies in the tribe Riodinini
- Seco (food), an Ecuadorian meat dish
- Seco (tobacco), the mid-level leaves of a tobacco plant
SECO may refer to:
- Second Engine Cut-Off, the shutdown of the second stage, a major milestone in the ascent of a multistage rocket
- The ICAO airport code for Francisco de Orellana Airport in Ecuador
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