RYR1

RYR1

Identifiers Symbols RYR1; CCO; MHS; MHS1; RYDR; RYR; RYR-1; SKRR External IDs OMIM: 180901 MGI: 99659 HomoloGene: 68069 IUPHAR: RyR1 ChEMBL: 1846 GeneCards: RYR1 Gene

Gene Ontology
Molecular function	• protease binding • ryanodine-sensitive calcium-release channel activity • voltage-gated calcium channel activity • calcium channel activity • calcium ion binding • calmodulin binding • calcium-release channel activity
Cellular component	• cytoplasm • smooth endoplasmic reticulum • plasma membrane • integral to plasma membrane • cell cortex • junctional sarcoplasmic reticulum membrane • terminal cisterna • sarcoplasmic reticulum • junctional membrane complex • T-tubule • I band • sarcoplasmic reticulum membrane
Biological process	• response to hypoxia • outflow tract morphogenesis • calcium ion transport • muscle contraction • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • response to caffeine • ion transmembrane transport • skin development • ossification involved in bone maturation • skeletal muscle fiber development • release of sequestered calcium ion into cytosol • cytosolic calcium ion homeostasis • transmembrane transport • cellular response to caffeine
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6261 20190 Ensembl ENSG00000196218 ENSMUSG00000030592 UniProt P21817 E9PZQ0 RefSeq (mRNA) NM_000540 NM_009109 RefSeq (protein) NP_000531 NP_033135 Location (UCSC) Chr 19:
38.92 – 39.08 Mb Chr 7:
29 – 29.13 Mb PubMed search

Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.