RHOA

RHOA

Identifiers Symbols RHOA; ARH12; ARHA; RHO12; RHOH12 External IDs OMIM: 165390 MGI: 1096342 HomoloGene: 68986 ChEMBL: 6052 GeneCards: RHOA Gene

Gene Ontology
Molecular function GTPase activity
protein binding
GTP binding
myosin binding
protein domain specific binding
Cellular component nucleus
mitochondrion
cytosol
cytoskeleton
plasma membrane
cell cortex
lamellipodium
cell junction
axon
midbody
cleavage furrow
ruffle membrane
apical junction complex
Biological process response to hypoxia
regulation of transcription from RNA polymerase II promoter
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
small GTPase mediated signal transduction
Rho protein signal transduction
axon guidance
skeletal muscle tissue development
blood coagulation
response to mechanical stimulus
response to glucose stimulus
virus-host interaction
actin cytoskeleton organization
platelet activation
positive regulation of cell growth
regulation of cell migration
positive regulation of cell migration
androgen receptor signaling pathway
positive regulation of actin filament polymerization
stress-activated protein kinase signaling cascade
negative regulation of intracellular steroid hormone receptor signaling pathway
regulation of osteoblast proliferation
cleavage furrow formation
positive regulation of NF-kappaB import into nucleus
response to drug
positive regulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of I-kappaB kinase/NF-kappaB cascade
stress fiber assembly
response to amino acid stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
apical junction assembly
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
ossification involved in bone maturation
response to ethanol
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of translation
positive regulation of cell adhesion
positive regulation of vasoconstriction
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
regulation of axonogenesis
negative regulation of axonogenesis
positive regulation of axonogenesis
regulation of dendrite development
regulation of small GTPase mediated signal transduction
response to glucocorticoid stimulus
positive regulation of stress fiber assembly
regulation of calcium ion transport
trabecula morphogenesis
positive regulation of podosome assembly
spindle assembly involved in mitosis
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 387 11848 Ensembl ENSG00000067560 ENSMUSG00000007815 UniProt P61586 Q9QUI0 RefSeq (mRNA) NM_001664 NM_016802 RefSeq (protein) NP_001655 NP_058082 Location (UCSC) Chr 3:
49.4 – 49.45 Mb Chr 9:
108.31 – 108.34 Mb PubMed search

Ras homolog gene family, member A (RhoA) is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. In humans, it is encoded by the gene RHOA.

It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (diaphanous homolog 1 (Drosophila)).

RhoA is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division.

Read more about RHOA:  RhoA Pathway, Interactions

Other articles related to "rhoa":

Kruppel-like Factors - Krüppel-like Factors 4 & 5 in The Vascular System
... effect of Klf4 on the PKG 1α promoter is inhibited by RhoA-induced actin polymerisation, possibly via G-actin regulation of a Klf4 co-activator or co-repressor ... RhoA signalling pathways and RhoA activation are implicated in hypertension and increased vascular resistance which to some extent can be explained by this interaction with Klf4 and its effects on the response to NO ...
DLC1 - Significance in Cancer - Tumor Suppressor Gene Activity
... in constitutive activation of the RhoGTPases RhoA and Cdc42 ... GTP-bound Rho-GTPases' (specifically, RhoA and Cdc42) intrinsic ability to convert their GTP into GDP, thus rendering them inactive ... The activity of RhoA regulates the formation of actin stress fibers and focal adhesions - complexes of many proteins located at the termini of actin stress fibers which link the ...
RHOA - Interactions
... RHOA has been shown to interact with Phospholipase D1, PLCG1, ARHGAP5, ARHGAP1, TRPC1, ITPR1, DIAPH1, GEFT, ARHGEF3, ARHGEF12, ARHGDIA, KCNA2, RAP1GDS1, DGKQ, TRIO, ROCK1, ARHGEF11, RICS, PKN2 ...
Netrin - Axonal Guidance - Repulsion
... repulsion though a possible activation of RhoA ... A similar RhoA-mediated mechanism is proposed for long range chemorepulsion whereby netrin-1 binding to UNC-5 homodimers alone motivates tyrosine phosphorylation ... to the netrin-1/UNC-5 complex may also trigger chemorepulsion through RhoA ...
Cingulin - Function
... on gene expression are thought to be mediated at least in part by the regulation of RhoA activity by cingulin, since they can be reversed by dominant-negative RhoA ... Indeed, cingulin interacts with the RhoA exchange factor GEF-H1, and inactivates it by recruiting it to junctions when cells reach confluence ... cingulin at mature junctions of confluent monolayers is one mechanism to down-regulate RhoA activity once cells reach confluence ...