RHOA

RHOA

Identifiers Symbols RHOA; ARH12; ARHA; RHO12; RHOH12 External IDs OMIM: 165390 MGI: 1096342 HomoloGene: 68986 ChEMBL: 6052 GeneCards: RHOA Gene

Gene Ontology
Molecular function	• GTPase activity • protein binding • GTP binding • myosin binding • protein domain specific binding
Cellular component	• nucleus • mitochondrion • cytosol • cytoskeleton • plasma membrane • cell cortex • lamellipodium • cell junction • axon • midbody • cleavage furrow • ruffle membrane • apical junction complex
Biological process	• response to hypoxia • regulation of transcription from RNA polymerase II promoter • cell-matrix adhesion • transforming growth factor beta receptor signaling pathway • small GTPase mediated signal transduction • Rho protein signal transduction • axon guidance • skeletal muscle tissue development • blood coagulation • response to mechanical stimulus • response to glucose stimulus • virus-host interaction • actin cytoskeleton organization • platelet activation • positive regulation of cell growth • regulation of cell migration • positive regulation of cell migration • androgen receptor signaling pathway • positive regulation of actin filament polymerization • stress-activated protein kinase signaling cascade • negative regulation of intracellular steroid hormone receptor signaling pathway • regulation of osteoblast proliferation • cleavage furrow formation • positive regulation of NF-kappaB import into nucleus • response to drug • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of I-kappaB kinase/NF-kappaB cascade • stress fiber assembly • response to amino acid stimulus • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • apical junction assembly • negative regulation of neuron apoptotic process • positive regulation of neuron apoptotic process • ossification involved in bone maturation • response to ethanol • negative regulation of neuron differentiation • positive regulation of neuron differentiation • positive regulation of translation • positive regulation of cell adhesion • positive regulation of vasoconstriction • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • regulation of axonogenesis • negative regulation of axonogenesis • positive regulation of axonogenesis • regulation of dendrite development • regulation of small GTPase mediated signal transduction • response to glucocorticoid stimulus • positive regulation of stress fiber assembly • regulation of calcium ion transport • trabecula morphogenesis • positive regulation of podosome assembly • spindle assembly involved in mitosis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 387 11848 Ensembl ENSG00000067560 ENSMUSG00000007815 UniProt P61586 Q9QUI0 RefSeq (mRNA) NM_001664 NM_016802 RefSeq (protein) NP_001655 NP_058082 Location (UCSC) Chr 3:
49.4 – 49.45 Mb Chr 9:
108.31 – 108.34 Mb PubMed search

Ras homolog gene family, member A (RhoA) is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. In humans, it is encoded by the gene RHOA.

It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (diaphanous homolog 1 (Drosophila)).

RhoA is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division.