Prelamin

Progeria - Research - Lamin A
... Prelamin A contains a CAAX box at the C-terminus of the protein (where C is a cysteine and A is any aliphatic amino acids) ... that the cysteine is farnesylated and allows prelamin A to bind membranes, specifically the nuclear membrane ... After prelamin A has been localized to the cell nuclear membrane, the C-terminal amino acids, including the farnesylated cysteine, are cleaved off by a specific protease ...

Research - Mouse Model of Progeria
... of progeria exists, though in the mouse, the LMNA prelamin A is not mutated ... the specific protease that is required to remove the C-terminus of prelamin A, is missing ... Both cases result in the buildup of farnesylated prelamin A on the nuclear membrane and in the characteristic nuclear LMNA blebbing ...