Plouffe is a surname. People with this surname include:
- David Plouffe (born 1967), American campaign manager
- Michelle Plouffe (born 1992), basketball player
- Simon Plouffe (born 1956), Quebec mathematician
- Trevor Plouffe (born 1986), American baseball player
- La Famille Plouffe, Quebec TV series of the 1950s (and revived in the 1980s)
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