PLEX or Plex may refer to:
- PLEX (programming language), a programming language used by Ericsson for their AXE telephone exchange
- Plex (software), media center software including a media server, and desktop and mobile clients
- Synon, CA Plex, a subsequent version of CA 2E (Synon) that generate C#, Java, C++, and RPG applications
- Prairie Lindy Exchange, an acronym used in various lindy exchanges in central North America
- Googolplex, a large number, which has given rise to "n-plex" notation in the names of large numbers
- Googleplex, corporate headquarters complex of Google, Inc.
- Light Water Reactor Sustainability Program or Plant Life Extension of nuclear power plants
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