Pernessa C. Seele (born 15 October 1954) is an immunologist and the CEO and founder of Balm in Gilead, Inc., a religious-based organization that provides support to people with AIDS and their families, as well as working for prevention of HIV and AIDS. In 1989 she initiated the Harlem Week of Prayer, with 50 churches, synagogues and mosques participating. This became an annual event and organizing force for the religious community to respond to the AIDS crisis.
Seele incorporated a growing organization as "The Balm in Gilead, Inc." This "national movement to address public-health issues through communities of faith" has grown to include more than ten thousand churches, and numerous branches in the United States, Africa and the Caribbean. After 30 years in New York, Seele and the organization are now based in Richmond, Virginia.