ODC may refer to:
- Obligatory Dangerousness Criterion, a clause in the mental health law of many countries
- ODC/Dance, a San Francisco based dance company
- Offshore development center, a business models for offshore programming
- Opera's DC++ (oDC), which is a DC++-based client for the Direct Connect network
- Open Data Commons
- ODBC (Open Database Connectivity, sometimes also abbreviated as ODC), a standard C programming language interface for accessing database management systems
- Ordinary Decent Criminal (slang)
- Ornithine decarboxylase, an enzyme
- Orthogonal Defect Classification
- Ozone depleting chemical, any chemical substance causing ozone depletion
.odc, a file suffix which can identify (inter alia) Microsoft Office "Office Data Connection" files