Immobilization may refer to:
- Automobile immobilization, the prevention of an automobile's engine from running
- Economic immobilization, a concept in financial economics
- Enzyme immobilization, a concept in organic chemistry
- Immobilization (pathology), a type of human position
- Immobilization (soil science), the absorption of decomposed organic matter by micro-organisms
- Molecular immobilization, a fictional magical power in the television series Charmed
- Muscle immobilization, the complete loss of muscle function for one or more muscle groups
- Whole cell immobilization, a biochemistry method
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