Caspase

Caspase

Caspases, or cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases are a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation.

Caspases are essential in cells for apoptosis, or programmed cell death, in development and most other stages of adult life, and have been termed "executioner" proteins for their roles in the cell. Some caspases are also required in the immune system for the maturation of lymphocytes. Failure of apoptosis is one of the main contributions to tumour development and autoimmune diseases; this, coupled with the unwanted apoptosis that occurs with ischemia or Alzheimer's disease, has stimulated interest in caspases as potential therapeutic targets since they were discovered in the mid-1990s.

Read more about Caspase:  Types of Caspase Proteins, Caspase Cascade, Discovery of Caspases, Functions

Other articles related to "caspase, caspases":

Caspase 14
... Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene ... The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis ...
Caspase 7
... Mb Chr 19 56.4 – 56.44 Mb PubMed search Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene ... Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis ...
AIM2 - Function
... the pyrin domain of another protein ASC (or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain) ... ASC also contains a CARD domain (caspase activation and recruitment domain), that recruits procaspase-1 to the complex ... This leads to the autoactivation of caspase-1, an enzyme that processes proinflammatory cytokines (IL-1b and IL-18) ...
Discovery of Caspases, Functions
... Robert Horvitz initially established the importance of caspases in apoptosis and found that the ced-3 gene is required for the cell death that took place ... properties to the mammalian interleukin-1-beta converting enzyme (ICE) (now known as caspase 1), which at the time was the only known caspase ... Other mammalian caspases were subsequently identified, in addition to caspases in organisms such as fruit fly Drosophila melanogaster ...
Caspase 6
... (UCSC) Chr 4 110.61 – 110.62 Mb Chr 3 129.9 – 129.91 Mb PubMed search Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene ... that is a member of the cysteine-aspartic acid protease (caspase) family ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis ...