The Bioinformatics Resource Centers (BRCs) are a group of five Internet-based research centers established in 2004 and funded by NIAID (the National Institute of Allergy and Infectious Diseases.) The BRCs were formed in response to the threats posed by emerging and re-emerging pathogens, particularly CDC Category A, B, and C pathogens, and their potential use in bioterrorism. The intention of NIAID in funding these bioinformatics centers is to assist researchers involved in the experimental characterization of such pathogens and the formation of drugs, vaccines, or diagnostic tools to combat them.
The main goals of the BRCs are as follows:
1) To create comprehensive databases of reliable, up-to-date bioinformatic data (genetic, proteomic, biochemical, or microbiological) related to the pathogens of interest;
2) To provide researchers with easy access to these data through Internet-based search and data retrieval user interfaces;
3) To provide researchers with relevant, state-of-the art computational tools for bioinformatic analysis of these data.
The five BRCs are supported by various institutions, both publicly and privately owned, throughout the USA and Canada. Each BRC focuses on a different group of pathogens. The Pathogen Portal serves as a common repository and provides summary information about and links into the BRCs.
| Name | Acrono name | Contributing organization(s) | Number of organisms covered | Organisms covered (CDC Category) |
|---|---|---|---|---|
| Eukaryotic Pathogen Database Resources | EuPathDB | University of Pennsylvania University of Georgia |
45 in 13 genera | Crithidia (Other) Cryptosporidium (B) |
| Influenza Research Database | IRD | Northrop Grumman Information Technology University of Texas Southwestern Medical Center |
1 | Influenza Virus (flu) (C) |
| PathoSystems Resource Integration Center | PATRIC | Virginia Bioinformatics Institute University of Chicago |
22 genera | Bacillus (A) Bartonella (Group I) |
| Virus Pathogen Database and Analysis Resource | ViPR | Northrop Grumman Information Technology University of Texas Southwestern Medical Center |
13 families | Arenaviridae (A) Bunyaviridae (A) |
| VectorBase | VB | University of Notre Dame European Bioinformatics Institute |
5 | Anopheles gambiae (Other) Aedes aegypti (Other) |
| Pathogen Portal | none | Virginia Bioinformatics Institute | Data for 13 species: Gene expression, proteomics |
Vaccinia (Other) Variola (A) |
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