Arroyo Seco (Spanish: "dry creek") may refer to:
Argentina:
- Arroyo Seco, Santa Fe
Mexico:
- Arroyo Seco, Querétaro
United States:
- Arroyo Seco, New Mexico
- Arroyo Seco (Alameda County), a watercourse in Alameda County, California
- Arroyo Seco (Los Angeles County), a watercourse in Los Angeles County, California
- Arroyo Seco (Salinas River), a watercourse in Monterey County, California
- Arroyo Seco AVA, California wine region in Monterey County
- Arroyo Seco Creek, a watercourse in Sonoma County, California
- Arroyo Seco Parkway, the first California freeway
- Arroyo Seco Raceway, a paved racetrack near Deming, New Mexico
Uruguay:
- Arroyo Seco, neighbourhood of Montevideo
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