Alexander II may refer to:
- Alexander II of Macedon, King of Macedon from 370 to 368 BC
- Alexander II of Epirus (died 260 BC), King of Epirus in 272 BC
- Pope Alexander II, Pope from 1061 to 1073
- Alexander II of Scotland (1198–1249), King of Scots
- Alexander II of Imereti (1478, 1483–1510), King of Georgia and of Imereti
- Alexander II of Kakheti (1574–1605), King of Kakheti
- Alexander II of Russia (1818–1881), Emperor of Russia
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