Uracil

Uracil ( /ˈjʊərəsɪl/) one of the four nucleobases in the nucleic acid of RNA that are represented by the letters A, G, C and U. The others are adenine, cytosine, and guanine. In RNA, uracil (U) binds to adenine (A) via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine.

Uracil is a common and naturally occurring pyrimidine derivative. Originally discovered in 1900, it was isolated by hydrolysis of yeast nuclein that was found in bovine thymus and spleen, herring sperm, and wheat germ. It is a planar, unsaturated compound that has the ability to absorb light.

Studies reported in 2008, based on 12C/13C isotopic ratios of organic compounds found in the Murchison meteorite, suggested that uracil, xanthine and related molecules were formed extraterrestrially.

In 2012 an analysis of data from the Cassini mission orbiting in the Saturn system showed that Titan's surface composition may include uracil.

Read more about Uracil:  Properties, Synthesis, Reactions, Uses

Other articles related to "uracil":

Efudex - Synthesis
... Since uracil is a normal component of RNA, the rationale behind the development of the drug was that cancer cells, with their increased genetic ... a drug which demonstrated specific uracil antagonism ... When elemental fluorine is reacted with uracil, 5-fluorouracil is produced ...
Uracil - Uses
... Uracil can be used for drug delivery and as a pharmaceutical ... When elemental fluorine is reacted with uracil, 5-fluorouracil is produced. 5-Fluorouracil is an anticancer drug (antimetabolite) used to masquerade as uracil during the nucleic acid replication process ...
Uracilylalanine Synthase
... that catalyzes the chemical reaction O3-acetyl-L-serine + uracil 3-(uracil-1-yl)-L-alanine + acetate Thus, the two substrates of this enzyme are O3-acetyl-L-serine and uracil, whereas its two products ... use include O3-acetyl-L-serine acetate-lyase (adding uracil), isowillardiine synthase, willardiine synthase, and 3-O-acetyl-L-serineuracil 1-(2-amino-2-carboxyethyl ...
Methylenetetrahydrofolate-t RNA-(uracil-5-)-methyltransferase
... a methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (EC 2.1.1.74) is an enzyme that catalyzes the chemical reaction 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH2 ... name of this enzyme class is 5,10-methylenetetrahydrofolatetRNA (uracil-5-)-methyl-transferase ... methylenetetrahydrofolate-transfer ribonucleate uracil, 5-methyltransferase, 5,10-methylenetetrahydrofolatetRNA-UPsiC, and (uracil-5-)-methyl-transferase ...
Cylindrospermopsin - Chemistry - Structure Determination
... molecule possesses a tricyclic guanidine group (rings A, B C), along with a uracil ring (D) ... to small changes in pH suggested that the uracil ring exists in a keto/enol tautomeric relationship, where a hydrogen transfer results in two distinct ... It was originally proposed that a hydrogen bond between the uracil and guanidine groups in the enol tautomer would make this the dominant form ...