Tumor Necrosis Factor

Tumor Necrosis Factor

Tumor necrosis factors (or the TNF family) refer to a group of cytokines whose family can cause cell death (apoptosis). The first two members of the family to be identified were:

  • Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia. The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers. Both the mature protein and a partially processed form of the hormone can be secreted after cleavage of the propeptide.
  • Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10.

Read more about Tumor Necrosis FactorFamily Members, Examples, Notes and References

Other articles related to "tumor necrosis factor, factor":

... production • positive regulation of tumor necrosis factor production • tumor necrosis factor-mediated signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway ...
829 ChEMBL 1250356 GeneCards TNFRSF1B Gene Gene Ontology Molecular function • tumor necrosis factor-activated receptor activity • protein binding • ubiquitin protein ligase binding Cellular component ... The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A ... by the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals ...
... regulation of interleukin-1 beta production • positive regulation of tumor necrosis factor production • positive regulation of protein import into nucleus ...
... protease binding • death receptor binding • tumor necrosis factor receptor binding • protein binding • tumor necrosis factor receptor superfamily binding • identical protein binding Cellular ...

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