Thioredoxin Reductase

Thioredoxin Reductase

Thioredoxin reductases (TR, TrxR) (EC 1.8.1.9) are the only known enzymes to reduce thioredoxin (Trx). Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. Both classes are flavoproteins which function as homodimers. Each monomer contains a FAD prosthetic group, a NADPH binding domain, and an active site containing a redox-active disulfide bond.

Read more about Thioredoxin Reductase:  Cellular Role, Diversity, Structure, Mechanism, Clinical Significance

Other articles related to "reductase, thioredoxin, thioredoxin reductase, thioredoxin reductases":

L-methionine (S)-S-oxide Reductase
... In enzymology, a L-methionine (S)-S-oxide reductase (EC 1.8.4.13) is an enzyme that catalyzes the chemical reaction L-methionine + thioredoxin disulfide + H2O L-methionine (S)-S-oxide ... Other names in common use include fSMsr, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionineoxidized-thioredoxin S-oxidoreduc ...
Thioredoxin Reductase - Clinical Significance
... leading to cell death and apoptosis via inhibition of thioredoxin reductase and ribonucleotide reductase ... Thioredoxin reductases are essential proteins for regulating cellular redox balance and mitigating the damage caused by reactive oxygen species generated via oxidative phosphorylation in the mitochondria ...
Mercury Toxicity - Mechanism
... its unique ability to irreversibly inhibit activities of selenoenzymes, such as thioredoxin reductase (IC50 = 9 nM) ... Although it has many additional functions, thioredoxin reductase restores vitamins C and E, as well as a number of other important antioxidant molecules ... selenium available for the biosynthesis of thioredoxin reductase and other selenoenzymes that prevent and reverse oxidative damage, which, if the depletion is severe ...
L-methionine (R)-S-oxide Reductase
... In enzymology, a L-methionine (R)-S-oxide reductase (EC 1.8.4.14) is an enzyme that catalyzes the chemical reaction L-methionine + thioredoxin disulfide + H2O L-methionine (R)-S-oxide + thioredoxin The 3 ... in common use include fRMsr, FRMsr, free met-R-(o) reductase, and free-methionine (R)-S-oxide reductase ...