Rh Disease

Rh disease (also known as Rhesus isoimmunisation, Rh (D) disease, Rhesus incompatibility, Rhesus disease, RhD Hemolytic Disease of the Newborn, Rhesus D Hemolytic Disease of the Newborn or RhD HDN) is one of the causes of hemolytic disease of the newborn (HDN). The disease ranges from mild to severe, and typically occurs only in some second or subsequent pregnancies of Rh negative women where the fetus's father is Rh positive, leading to a Rh+ pregnancy. During birth, the mother may be exposed to the infant's blood, and this causes the development of antibodies, which may affect the health of subsequent Rh+ pregnancies. In mild cases, the fetus may have mild anaemia with reticulocytosis. In moderate or severe cases the fetus may have a more marked anaemia and erythroblastosis (erythroblastosis fetalis). When the disease is very severe it may cause haemolytic disease of the newborn (HDN), hydrops fetalis, or stillbirth.

Rh disease is generally preventable by treating the mother during pregnancy or soon after delivery with an intramuscular injection of anti-RhD immunoglobulin (Rho(D) immune globulin). The RhD protein is coded for by the RHD gene.

Read more about Rh DiseaseSerology, Prevention, Blood Tests, Management, History of Medical Advances in Rh Disease

Other articles related to "rh disease, disease":

History of Medical Advances in Rh Disease
... who had a stillborn baby who died of hemolytic disease of the newborn ... The first treatment for Rh disease was an exchange transfusion, which was invented by Dr ... It led him to propose that the disease might be prevented by injecting the at-risk mother with an antibody against fetal red blood cells ...
Hydrops Fetalis - Classification and Causes - Immune Causes
... Rh disease is a cause for immune mediated hydrops fetalis however, owing to preventative methods developed in the 1970s Rh disease has markedly declined ... Rh disease can be prevented by administration of anti-D IgG (Rho(D) Immune Globulin) injections to RhD-negative mothers during pregnancy and/or within 72 hours of the delivery ... of pregnant mothers are still susceptible to Rh disease even after having been administered anti-D IgG (Rho(D) Immune Globulin) ...

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