A protein domain is a conserved part of a given protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be "swapped" by genetic engineering between one protein and another to make chimeric proteins.
Read more about Protein Domain: Background, Domains Are Units of Protein Structure, Domains As Evolutionary Modules, Multidomain Proteins, Domains and Protein Flexibility, Domain Definition From Structural Co-ordinates, See Also, References
Other articles related to "protein domain, domains, proteins, domain, protein":
... (2002) "Predicting Structural Domains in Proteins" Thesis, University College London, which were contributed by its author ...
... Thi particular structure has an alpha/beta central domain which is actually made up of three alpha helices and a mixed parallel/anti-parallel four-stranded beta-sheet ...
... Sushi_2 NMR structure of the fifth domain of human beta-2-glycoprotein I Identifiers Symbol Sushi_2 Pfam PF09014 InterPro IPR015104 Available protein structures Pfam structures PDB RCSB ... This protein domain is only found in eukaryotes ... The first four domains found in Apolipoprotein H resemble each other, however the fifth one appears to be different ...
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