Ossification

Ossification (or osteogenesis) is the process of laying down new bone material by cells called osteoblasts. It is synonymous with bone tissue formation. There are two processes resulting in the formation of normal, healthy bone tissue: Intramembranous ossification is the direct laying down of bone into the primitive connective tissue (mesenchyme), while endochondral ossification involves cartilage as a precursor. In fracture healing, endochondral osteogenesis is the most commonly occurring process, for example in fractures of long bones treated by plaster of Paris, whereas fractures treated by open reduction and stabilization by metal plate and screws may heal by intramembranous osteogenesis.

Heterotopic ossification is a process resulting in the formation of bone tissue that is often atypical, at an extraskeletal location. Calcification is often confused with ossification. Calcification is synonymous with the formation of calcium-based salts and crystals within cells and tissue. It is a process that occurs during ossification, but not vice versa.

The exact mechanisms by which bone development is triggered remains unclear, but it involves growth factors and cytokines in some way.


Read more about Ossification:  Timetable For Human Ossification, Evolution

Other articles related to "ossification":

Heterotopic Ossification - Causes
... Heterotopic ossification of varying severity can be caused by surgery or trauma to the hips and legs ... of the long bones of the lower leg will develop heterotopic ossification ... Between 50% and 90% of patients who developed heterotopic ossification following a previous hip arthoplasty will develop additional heterotopic ossification ...
Trochlea Of Humerus - Ossification
... While the ossification of the capitulum has started a year after birth, the ossification of the trochlea begins at 8–9 years of age that of the head of radius and the medial ...
List Of Subjects In Gray's Anatomy: II. Osteology - Bone (Gray's s18) - Gray's page #93
... Ossification intercartilaginous ossification epiphysial cartilage center of ossification primary areolæ perichondrium ...
Ossification Center
... The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed an ossification center, enlarge ...