MPTP

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin precursor to MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. It has been used to study disease models in various animal studies.

While MPTP itself has no psychoactive effects, the compound may be accidentally produced during the manufacture of MPPP, a synthetic opioid drug with effects similar to those of morphine and pethidine (meperidine). The Parkinson-inducing effects of MPTP were first discovered following accidental ingestion as a result of contaminated MPPP.

Read more about MPTPToxicity, Discovery in Users of Illicit Drugs, Contribution of MPTP To Research Into Parkinson's Disease, Synthesis and Uses, In Popular Culture

Other articles related to "mptp":

Desmethylprodine - As A Designer Drug - Toxic Impurity
... anhydride at an elevated temperature, MPTP was formed as a major impurity. 1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible symptoms similar to Parkinson's Disease ... MPTP is metabolized to the neurotoxin MPP+ by the enzyme MAO-B, which is expressed in glial cells ...
MPTP - In Popular Culture
... In the novel Neuromancer, authored by William Gibson, MPTP is used as a means of inducing parkinsonism to a character ... after deleterious effects of this compound were first described, it depicts quite accurately how MPTP destroys dopaminergic neurons of the substantia nigra ...
PEPAP
... of PEPAP are neurotoxic in the same way as the MPPP byproduct MPTP ... It appears that the N-methyl group of MPTP is required for neurotoxic activity ... In animal experiments, only MPTP analogues that preserved the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine structure were active as dopaminergic neurotoxins ...
List Of Misconceptions About Illegal Drugs - MDMA (ecstasy) - MDMA Causes Parkinson's Disease
... The neurotoxicity of MPTP was first hinted at in 1976 after Barry Kidston, a 23-year-old chemistry graduate student in Maryland, synthesized MPPP (a synthetic opiate related to pethidine and the prodines) with ... The National Institute of Mental Health found traces of MPPP, MPTP, and other pethidine analogues in his lab ... Clara County, California were diagnosed with Parkinsonism after having used MPPP contaminated with MPTP ...
Chemical Modification of The Substantia Nigra - MPTP
... See also MPTP MPTP, is a neurotoxin specific to dopaminergic cells in the brain, specifically in the substantia nigra ... MPTP was brought to the spotlight in 1982 when heroin users in California displayed Parkinson's-like symptoms after using MPPP contaminated with MPTP ... The proposed mechanism of MPTP involves disruption of mitochondrial function, including disruption of metabolism and creation of free radicals ...