Lens Fibers

Galactosemic Cataract - Ensuing Osmotic Pressure
... As galactitol concentration increases in the lens, a hypertonic environment is created ... Osmosis favors the movement of water into the lens fibers to reduce the high osmolarity ... as galactitol concentration increases inside the lens of galactosemic animals sustained on a galactose diet ...

Galactosemic Cataract - Changes in Lens That Accompany Galactitol Accumulation and Osmotic Swelling
... progresses due to galactitol synthesis and subsequent osmotic swelling, changes occur in the lens epithelial cells ... in high-galactose mediums, a nearly 40% reduction in lens amino acid levels is observed, along with significant ATP reduction as well ... these experiments it would appear that the loss of amino acids in the lens when exposed to galactose is primarily due to the osmotic swelling of the lens brought about by dulcitol retention ...

Galactosemic Cataract - Building On Friedenwald and Kinoshita
... Lens fibers became liquefied after nine days of the diet, and nuclear cataract formation appeared after 15 days of the diet ... Apoptosis in lens epithelial cells (LEC) is linked to cataract formation ... by Friedenwald and Kinoshita, which centers on osmotic swelling of the lens fibers, is just the beginning in a cascade of events that causes and progresses the galactosemic cataract ...