Growth Hormone

Growth hormone (GH) is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other animals. It is a type of mitogen which is specific only to certain kinds of cells. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. Somatotropin (STH) refers to the growth hormone 1 produced naturally in animals, whereas the term somatropin refers to growth hormone produced by recombinant DNA technology, and is abbreviated "HGH" in humans.

Growth hormone is used as a prescription drug in medicine to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies, by prescription from a doctor. In recent years in the United States, some doctors have started to prescribe growth hormone in GH-deficient older patients (but not on healthy people) to increase vitality. While legal, the efficacy and safety of this use for HGH has not been tested in a clinical trial. At this time, HGH is still considered a very complex hormone, and many of its functions are still unknown.

In its role as an anabolic agent, HGH has been abused by competitors in sports since the 1970s, and it has been banned by the IOC and NCAA. Traditional urine analysis could not detect doping with HGH, so the ban was unenforceable until the early 2000s when blood tests that could distinguish between natural and artificial HGH were starting to be developed. Blood tests conducted by WADA at the 2004 Olympic Games in Athens, Greece targeted primarily HGH. This use for the drug is not approved by the FDA.

GH has been studied for use in raising livestock more efficiently in industrial agriculture and several efforts have been made to obtain governmental approval to use GH in livestock production. These uses have been controversial. In the United States, the only FDA-approved use of GH for livestock is the use of a cow-specific form of GH called bovine somatotropin for increasing milk production in dairy cows. Retailers are permitted to label containers of milk as produced with or without bovine somatotropin.

Read more about Growth Hormone:  Non-medical Use in Athletic Enhancement, Use of GH in Production of Meat and Milk, History of Use and Manufacture of GH As A Drug, Dietary Supplements Claiming Relation To GH

Other articles related to "growth hormone, growth, hormone, hormones":

SOCS2
... Gene Gene Ontology Molecular function • SH3/SH2 adaptor activity • growth hormone receptor binding • prolactin receptor binding • insulin-like growth factor ... found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling ... suggested a regulatory role of this gene in IGF-1 related growth control ...
Pituitary Disease
... involving the pituitary gland are Condition Direction Hormone Acromegaly overproduction growth hormone Cushing's disease overproduction Adrenocorticotropic hormone Growth hormone deficiency underproduction ... example insufficient production (hyposecretion) of thyroid stimulating hormone (TSH) in the pituitary gland will cause hypothyroidism, while overproduction (hypersecretion) of TSH will cause hyperthyroidism ...
SM-130,686
... SM-130,686 is a drug which acts as a potent, orally active growth hormone secretagogue, with around half the potency of the endogenous agonist ghrelin as a stimulator of growth hormone release ... mass and decrease in body fat, and is under investigation for the treatment of growth hormone deficiency and other medical conditions ... drug for athletes have led to the development of urine tests for SM-130,686 and other growth hormone secretagogues, even though no drugs from this class have yet progressed to clinical use ...
Endocrine Glands - Major Endocrine Organs - Pituitary Gland (hypophysis)
... It consists of a hormone-producing glandular portion (anterior pituitary) and a neural portion (posterior pituitary), which is an extension of the ... anterior pituitary and synthesizes two hormones that it exports to the posterior pituitary for storage and later release ... Four of the six adenohypophyseal hormones are tropic hormones that regulate the function of other endocrine organs ...

Famous quotes containing the word growth:

    Cities force growth and make men talkative and entertaining, but they make them artificial. What possesses interest for us is the natural of each, his constitutional excellence. This is forever a surprise, engaging and lovely; we cannot be satiated with knowing it, and about it; and it is this which the conversation with Nature cherishes and guards.
    Ralph Waldo Emerson (1803–1882)