Gpcr

Raymond C. Stevens - Scientific Career
... in understanding how the G protein-coupled receptor (GPCR) superfamily works ... for Structural Genomics, Joint Center for Innovative Membrane Protein Technologies, and the GPCR Network, all funded by the National Institutes of Health with direct guidance from NIGMS ... and colleagues published the first high-resolution structure of a human GPCR ...

Pepducin
... receptor loops to modulate GPCR action in targeted cell-signaling pathways ... A Pepducin molecule comprises a short peptide derived from a GPCR intracellular loop tethered to a hydrophobic moiety ... lipopeptides to anchor in the cell membrane lipid bilayer and target the GPCR/G protein interface via a unique intracellular allosteric mechanism ...

Peng Chong - GPCR
... Peng was denounced by the Red Guard in 1967 for his official visit to the USSR and his post-trip comment that China might learn something from Soviet art ... Nevertheless, he was named the sole civilian provincial Revolutionary Committee Vice Chair in March 1968 ...

G Protein-coupled Receptors - Receptor Regulation
... GPCRs become desensitized when exposed to their ligand for a prolonged period of time. 1) homologous desensitization, in which the activated GPCR is downregulated and 2) heterologous desensitization, wherein the activated GPCR causes downregulation of a different GPCR ...

CAMP-dependent Pathway - Mechanism
... G protein-coupled receptors (GPCRs) are a large family of integral membrane proteins that respond to a variety of extracellular stimuli ... Each GPCR binds to and is activated by a specific ligand stimulus that ranges in size from small molecule catecholamines, lipids, or neurotransmitters to large protein hormones ... When a GPCR is activated by its extracellular ligand, a conformational change is induced in the receptor that is transmitted to an attached intracellular heterotrimeric G protein complex ...