GFR

Tubuloglomerular Feedback
... the kidney uses to regulate glomerular filtration rate (GFR) ... Changes in GFR are detected by the renal tubule, which sends feedback signals to the glomerulus, initiating a cascade of events that ultimately brings GFR to an ...

Receptor Tyrosine Kinases - Families - RET Receptor Family
... themselves are classified as members of the GDNF receptor-α (GFRα) protein family ... Different members of the GFRα family (GFRα1-GFRα4) exhibit a specific binding activity for a specific GFLs ... Upon GFL-GFRα complex formation, the complex then brings together two molecules of RET, triggering trans-autophosphorylation of specific tyrosine residues within the tyrosine kinase domain of each RET molecule ...

Tubuloglomerular Feedback - Background
... When tubular flow (that is, GFR) lies outside this range, the ability of the nephron to maintain solute and water balance is compromised ... Additionally, changes in GFR may result from changes in renal blood flow (RBF), which itself must be maintained within narrow limits ... Tubuloglomerular feedback provides a mechanism by which changes in GFR can be detected and rapidly corrected for on a minute-to-minute basis as well as over sustained periods ...

Loop Diuretic Resistance
... to the kidneys, which decreases the glomerular filtration rate (GFR) and reduces the ability of loop diuretics to reach their target organ, the loop of Henle ... Similarly, non-steroidal anti-inflammatory drugs also decrease GFR with comparable results ... In patients with reduced GFR, ceiling dosages of loop diuretics are increased proportional to the decrease in GFR ...