The basic premise of the eu-FEDS hypothesis is that both soluble and cell surface associated glycoproteins, present in the reproductive system and expressed on gametes, suppress any potential immune responses, and inhibit rejection of the fetus. The eu-FEDS model further suggests that specific carbohydrate sequences (oligosaccharides) are covalently linked to these immunosuppressive glycoproteins and act as "functional groups" that suppress the immune response. The major uterine and fetal glycoproteins that are associated with the eu-FEDS model in the human include alpha-fetoprotein, CA125, and glycodelin-A (also known as placental protein 14 (PP14)).
Normally, a low level of these glycoproteins is detected in the maternal serum during the early stages of pregnancy. It appears that the effects of these eu-FEDS associated glycoproteins are manifested only during implantation and the very early development of the embryo. In humans, the expression of such glycoproteins greatly decreases toward the end of the first trimester. Therefore, more highly targeted mechanisms of immune suppression (such as the expression of the enzyme indoleamine dioxygenase (IDO)) are likely employed by the fetus during the subsequent stages of development. One potential reason for early inactivation of the system is that the immunosuppressive effect of these glycoproteins may be so complete that their continued leakage into the circulatory system could lead to a global suppression of the maternal immune response, compromising the mother's ability to carry the fetus to term.
Read more about this topic: Eutherian Fetoembryonic Defense System (eu-FEDS) Hypothesis
Other articles related to "hypothesis":
... picks a question of interest, and based on previous knowledge, develops a hypothesis ... The scientist then designs a controlled experiment which will allow him to test the hypothesis against the real world ... about the outcome of the test, based on the hypothesis ...
... The first hypothesis is that the evolution of schreckstoff has been driven by kin selection (Smith 1992) ... Support for this hypothesis would include evidence that individuals live in groups of closely related kin and that the release of chemical alarm signals increases the likelihood ... The second hypothesis, predator attraction, suggests that the release of schreckstoff may attract additional predators which will interfere with the predation event, increasing the likelihood that the ...
... The PANDAS diagnosis and the hypothesis that symptoms in this subgroup of patients are caused by infection are controversial ... Researchers are pursuing the hypothesis that the mechanism is similar to that of rheumatic fever, an autoimmune disorder triggered by streptococcal infections, where ... The molecular mimicry hypothesis is a proposed mechanism for PANDAS this hypothesis is that antigens on the cell wall of the streptococcal bacteria are similar in some way to the ...
... The hypothesis of directed mutagenesis was first proposed in 1988 by John Cairns, of Harvard University who was studying Escherichia coli that lacked the ... Later support for this hypothesis came from Susan Rosenberg, then at the University of Alberta, who found that an enzyme involved in DNA recombinational repair, recBCD, was ... The directed mutagenesis hypothesis was challenged in 2002, when John Roth and colleagues showed that the phenomenon was due to general hypermutability due to selected gene amplification, and was ...
Famous quotes containing the word hypothesis:
“It is a good morning exercise for a research scientist to discard a pet hypothesis every day before breakfast. It keeps him young.”
—Konrad Lorenz (19031989)
“It is an hypothesis that the sun will rise tomorrow: and this means that we do not know whether it will rise.”
—Ludwig Wittgenstein (18891951)
“Oversimplified, Merciers Hypothesis would run like this: Wit is always absurd and true, humor absurd and untrue.”
—Vivian Mercier (b. 1919)