DNA Sequencing

DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. It includes any method or technology that is used to determine the order of the four bases—adenine, guanine, cytosine, and thymine—in a strand of DNA. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery.

Knowledge of DNA sequences has become indispensable for basic biological research, and in numerous applied fields such as diagnostic, biotechnology, forensic biology, and biological systematics. The rapid speed of sequencing attained with modern DNA sequencing technology has been instrumental in the sequencing of complete DNA sequences, or genomes of numerous types and species of life, including the human genome and other complete DNA sequences of many animal, plant, and microbial species.

The first DNA sequences were obtained in the early 1970s by academic researchers using laborious methods based on two-dimensional chromatography. Following the development of fluorescence-based sequencing methods with automated analysis, DNA sequencing has become easier and orders of magnitude faster.

Read more about DNA SequencingUse of Sequencing, History, sequencing">Advanced Methods and de Novo Sequencing, Next-generation Methods, Methods in Development, Development Initiatives

Other articles related to "dna sequencing, sequencing, dna":

Jonathan M. Rothberg - Education and Scientific Career
... in the field of massively parallel DNA sequencing ... by Roche Diagnostics, and Ion Torrent, companies that have commercialized technologies for DNA sequencing that have significantly reduced the cost of sequencing a genome ... as uncovering the complexity of life in the World's oceans and sequencing the extinct wooly mammoth ...
Applied Biosystems - History
... its second commercial instrument, the Model 380A DNA Synthesizer, which made oligonucleotides, short DNA strands, for polymerase chain reaction (PCR), DNA ... with the desired protein's DNA sequence ... Automated DNA sequencing began at the California Institute of Technology, using fluorescent dyes, with Rights to the technology granted to Applied Biosystems ...
M13 Bacteriophage - Links
... Cloning Vehicles Their Contribution to DNA Sequencing, "M13 cloning vehicles ... Their contribution to DNA sequencing.", Methods Mol ... ISBN 0-89603-248-5, PMID 8220775 Included in DNA Sequencing Protocols by Griffin, Annette M ...
Daniel Tillett
... is a scientist working in the area of genomics, bioinformatics and DNA sequencing ... Daniel Tillett is the inventor of ASIN DNA amplification method, the UniSeq primer walking approach, the CounterTrace DNA sequencing software, the LongTrace DNA sequencing ...
DNA Sequencing - Development Initiatives
... Foundation established an initiative to promote the development of full genome sequencing technologies, called the Archon X Prize, intending to award $10 million to "the first ... include continuing work in microfluidic, polony and base-heavy sequencing methodologies ...

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