Cohesin - Function


The cohesin ring has three functions:

1. It is used to keep the sister chromatids connected with each other during metaphase ensuring that during mitosis (and meiosis), each sister chromatid segregates to opposite poles. Without cohesin, the cell would be unable to control sister chromatid segregation since there would be no way of ensuring whether the spindle fiber attached on each sister chromatid is from a different pole.

2. It facilitates spindle attachment onto chromosomes.

3. It facilitates DNA repair by recombination.

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