Cathelicidin

Cathelicidin-related antimicrobial peptides are a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes (PMNs). Cathelicidins serve a critical role in mammalian innate immune defense against invasive bacterial infection.

Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain.

Cathelicidin peptides have been isolated from many different species of mammals. Cathelicidins were originally found in neutrophils but have since been found in many other cells including epithelial cells and macrophages after activation by bacteria, viruses, fungi, or the hormone 1,25-D, which is the hormonally active form of vitamin D.

The cathelicidin family shares primary sequence homology with the cystatin family of cysteine proteinase inhibitors, although amino acid residues thought to be important in such protease inhibition are usually lacking.

Read more about CathelicidinCharacteristics, Family Members, Clinical Significance

Other articles related to "cathelicidin, cathelicidins":

Cathelicidin - Clinical Significance
... Patients with rosacea have elevated levels of cathelicidin and elevated levels of stratum corneum tryptic enzymes (SCTEs) ... Higher levels of human cathelicidin antimicrobial protein (hCAP18), which are regulated by vitamin D, appear to significantly reduce the risk of death from infection in ...
Skin Flora - Skin Defenses - Antimicrobial Peptides
... The skin creates antimicrobial peptides such as cathelicidins that control the proliferation of skin microbes ... Cathelicidins not only reduce microbe numbers directly but also cause the secretion of cytokine release which induces inflammation, angiogenesis, and ... such as atopic dermatitis have been linked to the suppression in cathelicidin production ...