In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index like many chemotherapy medications. Typically there is a 4-10 fold variation in cytotoxic drug clearance between individuals due to differing activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of cancer recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
Read more about Body Surface Area: Uses, Calculation, Average Values
Famous quotes containing the words body, surface and/or area:
“When an Indian is burned, his body may be broiled, it may be no more than a beefsteak. What of that? They may broil his heart, but they do not therefore broil his courage,—his principles. Be of good courage! That is the main thing.”
—Henry David Thoreau (1817–1862)
“In Manhattan, every flat surface is a potential stage and every inattentive waiter an unemployed, possibly unemployable, actor.”
—Quentin Crisp (b. 1908)
“I am aware of the damp souls of housemaids
Sprouting despondently at area gates.”
—T.S. (Thomas Stearns)