Binding Site

In biochemistry, a binding site is a region on a protein, DNA, or RNA to which specific other molecules and ions—in this context collectively called ligands—form a chemical bond.

Binding sites also exist on antibodies as specifically coded regions that bind antigens based upon their structure.

The term saturation refers to the fraction of total binding sites that are occupied at any given time. When more than one type of ligand can bind to a binding site, competition ensues.

An equilibrium exists between unbound ligands and bound ligands.

Binding sites also exhibit chemical specificity, a measure of the types of ligands that will bond, and affinity, which is a measure of the strength of the chemical bond.

Binding sites are often an important component of the functional characterization of biomolecules. For example, the characterization the binding site of a substrate to an enzyme is essential to model the reaction mechanism responsible for the chemical change from substrate to product.

A more specific type of binding site is the transcription factor binding site, present on DNA.

Other articles related to "binding site, binding sites, binding":

TFAP2A - Clinical Significance
... A disruption of an AP-2 alpha binding site in an IRF6 enhancer is associated with cleft lip ... Analysis of transcription factor binding site analysis showed that the risk allele disrupt a binding site for AP-2 alpha ...
Shikimate Dehydrogenase - Structure - C Terminal Domain
... Shikimate dehydrogenase also has an NADPH binding site that contains a Rossmann fold ... This binding site normally contains a glycine P-loop ... Hydrophobic interactions occur between the domains and the NADPH binding site ...
Ch IP-sequencing - Sensitivity
... By integrating a large number of short reads, highly precise binding site localization is obtained ... Compared to ChIP-chip, ChIP-seq data can be used to locate the binding site within few tens of base pairs of the actual protein binding site ... Tag densities at the binding sites are a good indicator of protein–DNA binding affinity, which makes it easier to quantify and compare binding affinities of a protein to ...
Discovery And Development Of Triptans - Design - Important Structural Features of Triptans and Binding To The Receptor
... The following chemical attributes on 5-HT1B/1D agonists have been found to contribute to the binding/efficacy on the 5-HT1B and 5-HT1D receptors An aromate Protonated nitrogen (ion bonds ... This can increase binding ability of the compound and the efficacy, especially with the 5-HT1D receptor ... A schematic drawing of the binding of sumatriptan to 5-HT1D receptor can be seen in figure 2 ...

Famous quotes containing the words site and/or binding:

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    What is lawful is not binding only on some and not binding on others. Lawfulness extends everywhere, through the wide-ruling air and the boundless light of the sky.
    Empedocles 484–424 B.C., Greek philosopher. The Presocratics, p. 142, ed. Philip Wheelwright, The Bobbs-Merrill Co., Inc. (1960)