Angiotensin

Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the release of aldosterone, another hormone, from the adrenal cortex. Aldosterone promotes sodium retention in the distal nephron, in the kidney, which also drives blood pressure up.

Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system. Angiotensin was independently isolated in Indianapolis and Argentina in the late 1930s (as 'angiotonin' and 'hypertensin', respectively) and subsequently characterised and synthesized by groups at the Cleveland Clinic and Ciba laboratories in Basel, Switzerland.

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Other articles related to "angiotensin":

Angiotensin - Effects - Renal
... Angiotensin II has a direct effect on the proximal tubules to increase Na+ reabsorption ... High concentrations of Angiotensin II can constrict the glomerular mesangium, reducing the area for glomerular filtration ... Angiotensin II as a sensitizer to tubuloglomerular feedback, preventing an excessive rise in GFR ...
C9orf3 - Function
... Also able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway ...
Moexipril
... Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) which is used for the treatment of hypertension and congestive heart failure ... It works by inhibiting the conversion of angiotensin I to angiotensin II ...
CYT006-Ang Qb - Method of Action
... Angiotensin II causes blood vessels to constrict, and drives blood pressure up ... immune system to produce antibodies which reduce angiotensin II blood levels, lowering blood pressure ...
Saralasin
... Saralasin is a partial agonist of angiotensin II receptors, though It is commonly mistaken as a competitive antagonist ... reduced hypertension) is only observed in patients with high plasma angiotensin II levels, but in patients with low angiotensin II levels Saralasin causes ... In other words, the effects of Saralasin on the angiotensin II receptor in the absence of angiotensin II is pharmacodynamically similar to angiotensin II itself thus it is a partial agonist, because if it ...