What is local anesthetic?

Local Anesthetic

A local anesthetic (LA) is a drug that causes reversible local anesthesia, generally for the aim of having a local analgesic effect, that is, inducing absence of pain sensation, although other local senses are often affected as well. Also, when it is used on specific nerve pathways (nerve block), paralysis (loss of muscle power) can be achieved as well.

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Some articles on local anesthetic:

Local Anesthetic - History
... It is believed that the local anesthetic effect of coca was also known and used for medical purposes ... Cocaine was isolated in 1860 and first used as a local anesthetic in 1884 ... substitute led to the development of the aminoester local anesthetics stovaine in 1903 and procaine in 1904 ...
Digesic - Toxicity
... In addition, both propoxyphene and its metabolite norpropoxyphene have local anesthetic effects at concentrations about 10 times those necessary for opioid effects ... Norpropoxyphene is a more potent local anesthetic than propoxyphene, and they are both more potent than lidocaine ... Local anesthetic activity appears to be responsible for the arrhythmias and cardiovascular depression seen in propoxyphene poisoning ...
Anesthesia Of The Brachial Plexus - Complications
... block include intra-arterial or intravenous injection, which can lead to local anesthetic toxicity ... Cardiovascular effects of local anesthetic toxicity include slowing of the heart rate and impairment of its ability to pump blood through the circulatory system, which may lead to circulatory collapse ... supraclavicular blocks include inadvertent subarachnoid or epidural injection of local anesthetic, which can result in respiratory failure ...
Local Anesthetic Toxicity
... While generally safe, local anesthetic agents can be toxic if used in excessive doses or administered improperly ... properly, patients may still experience unintended reactions to local anesthetics ... Repetitive (small) doses of local anesthetic to achieve an adequate level of anesthesia may lead to eventual administration of toxic doses ...

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