What are apoptosis?

  • (noun): A type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival.
    Synonyms: programmed cell death, caspase-mediated cell death


Apoptosis ( /ˌæpəˈtoʊsɪs/) is the process of programmed cell death (PCD) that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation. (See also apoptotic DNA fragmentation.)

Read more about Apoptosis.

Some articles on apoptosis:

Fragmentation (cell Biology) - Apoptosis
... Apoptosis refers to the demise of cells by programmed cell death, marked by a well-defined sequence of morphological changes ... the main morphological changes in the apoptosis process ... Extensive morphological and biochemical changes during apoptosis ensure that dying cells leave minimal impact on neighboring cells and/or tissues ...
Apoptosis Protein Subcellular Location Prediction
... In 2003, a method was developed for predicting subcellular location of apoptosis proteins Subsequently, various modes of Chou's pseudo amino acid composition ...
... Apoptosis-inducing factor 2 is a protein that in humans is encoded by the AIFM2 gene ... The protein encoded by this gene has significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF ... Overexpression of this gene has been shown to induce apoptosis ...
Mitochondrial Apoptosis-induced Channel
... The Mitochondrial Apoptosis-Induced Channel (or MAC), is an early marker of the onset of apoptosis ... Members of the Bcl-2 protein family regulate apoptosis by controlling the formation of MAC the pro-apoptotic members Bax and/or Bak form MAC, whereas the anti-apoptotic ... end result is prevention of cytochrome c release and apoptosis ...
... study was carried out to evaluate the role of c-Jun in cellular proliferation and apoptosis of the endometrium throughout the menstrual cycle ... the cyclic change of the c-jun protein levels is significant in the proliferation and apoptosis of glandular epithelial cells ... persistent stromal expression of c-jun protein may prevent stromal cells from entering into apoptosis during the late secretory phase ...