TTS is a three-letter abbreviation that may refer to:
- Computing and video games
- Teletypesetter
- Text-To-Speech
- Trouble Ticket System - a former name of Issue tracking system
- Metal Gear Solid: The Twin Snakes
- Education and schools
- Tanglin Trust School
- Thomas Telford School
- Music
- The Twilight Sad, indie band from Scotland.
- TaeTiSeo, spin of group of South Korean girl band Girls' Generation
- Touch the Sky - a single by Kanye West
- Science and medicine
- TTS, trade name for Disulfiram
- T Tauri Star
- Tarsal tunnel syndrome, foot condition
- Three-taxon analysis, a method of phylogenetic reconstruction
- Transdermal Therapeutic System
- Type three secretion (microbiology)
- Transportation
- Tanker Transport Services BV, Dutch barge tanker transportation company
- 'Track Transit System' or 'Tracked Transit System' airport people movers
- Other
- Taman Tasik Semenyih, a municipal student town in Kuala Lumpur, Malaysia
- Tamil Nadu Theological Seminary
- The Truman Show, a comedy movie starring Jim Carrey
- TTS Marine
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