TLE may stand for:
- Kimber Custom TLE II, a type of handgun manufactured by Kimber Manufacturing. TLE stands for Tactical Law Enforcement.
- Tag Logical Element (IBM AFP Structured Field)
- Target Location Error, the difference between the actual location of a target and its expected location
- Technology and Livelihood Education, one of the learning areas of the Secondary Education Curriculum in the Philippines.
- Temporal lobe epilepsy, a form of epilepsy characterized by recurrent seizures.
- The Living End, band
- The Lost Experience, an Alternate Reality Game based on the Lost TV Series
- Total Lipid Extract
- Total lunar eclipse, occurs when the moon passes behind the earth such that the earth blocks the sun’s rays from striking the moon.
- Transient luminous event, mysterious electrical phenomena that occur above storm clouds.
- Two-line element set, a format for distributing orbital elements data.
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