Schiller–Duval body is a cellular structure seen by microscope in endodermal sinus tumors (yolk sac tumors) which are the most common testicular cancer in children. Schiller-Duval bodies are present in approximately 50% of these tumors, and if found are pathognomonic. They are named for Mathias-Marie Duval and Walter Schiller who described them in the late nineteenth century.
Schiller–Duval bodies are said to resemble a glomerulus. They have a mesodermal core with a central capillary, all lined by flattened layers of both visceral and parietal cells. Immunofluorescent stain may show eosinophilic hyalin-like globules both inside and outside the cytoplasm that contain AFP and alpha 1-antitrypsin.
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“Man may have his opinion as to the relative importance of feeding his body and nourishing his soul, but he is allowed by Nature to have no opinion whatever as to the need for feeding the body before the soul can think of anything but the body’s hunger.”
—George Bernard Shaw (1856–1950)